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KMID : 1123920070210030760
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Korean Journal of Oriental Physiology and Pathology
2007 Volume.21 No. 3 p.760 ~ p.764
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Immunomodulating Activity of BL18 (Ganshu) Acupuncture on the Experimental Liver Metastasis Model of Mice
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Kim Myoung-Dong
Lee Soo-Jin
Kim Sung-Hoon
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Abstract
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We investigated that the immunomodulating activity of BL18 (Ganshu) acupuncture on the experimental liver metastasis model of mice. NA (non-acupoint)- and BL18-treatment enhanced the mitogenic activity of BALB/c whole splenocytes induced by various mitogenic stimuli. Acupuncture treatment tended to increase splenocytes differentiation even though did not show significance. Acupuncture treatment caused a marked increase of production of Th1 cytokine (IFN-) and Th2 cytokine (IL-4) by splenocytes and IL-12 and IFN-Y by macrophages. The increase of cytokine production on BL18-treated group was more pronounced compared to NA-treated group. The liver weight of NA- and BL18-treated group decreased compared to tumor group, but did not showed significant differences.
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KEYWORD
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Acupuncture, BL18, Macrophages, Cytokine
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